AVALIAÇÃO DO DEHIDROEPIANDROSTERONA (DHEA) NO GANHO DE MASSA MUSCULAR E COMPROMETIMENTO FISIOLÓGICO EM RATOS

Abstract

DHEA (dehydroepiandrosterone) is a precursor of the hormone testosterone, produced by the adrenal glands, released by the pituitary and testicular steroidogenesis in response to corticotropin stimulation. For lack of literature that describes their benefits, this has been used for nutritional supplementation indiscriminately. Therefore the objective of this study is to examine whether DHEA compromise the function of vital organs such as kidneys, liver, skeletal muscle and nervous system if its use can alter gain muscle mass and increase hormone levels. For this Wistar animals are treated with DHEA 25 mg tablet daily for one month and then sacrificed for biochemical analysis of cholesterol, estradiol, testosterone, androstenedione and histopathologic evaluation of the kidneys, liver, skeletal muscle and nervous system. Hoping that the results reveal clarification for future administration of DHEA. Index Terms - DHEA, hormone, rats, testosterone, histopathology.