DETERMINAÇÃO SIMULTÂNEA DE DIPIRONA, CLONIDINA E CETOCONAZOL EM ÁGUAS DE ABASTECIMENTO PÚBLICO ATRAVÉS DE UM SENSOR A BASE DE QUITOSANA

Abstract

The monitoring of drug presence onenvironment has been growing as research interest aboutanthropogenic impact on aquatic biota. For instance, theindiscriminate use of antibiotic drugs has the increase inmicrobiological resistance, as well as a contamination ofwater resources, as a direct consequence. The chitosan is abiologically inert material which has great adsorptivecapacity. In this work we propose a development of anelectrochemical sensor based on chitosan applied to drugsanalysis and monitoring. Some drugs from differentchemical classes and from different pharmacological andphysicochemical properties were chosen as models forapplication. Ketoconazole, dipyridamole and clonidinepresented oxidation processes well defined, which allowedthe definition of analytical parameters, such as linear rangeand detection limit. There was also the possibility ofsimultaneous analysis of dipyridamole and clonidine in acidmedium and analysis of ketoconazole by reduction.

Index Terms - voltammetry, quitosan, drugs.