AFLATOXINA E SUA RELAÇÃO COM O HEPATOCARCINOMA

Abstract

Although the risk to humans is unknown, there
is strong evidence that aflatoxin contributes to liver
cirrhosis and liver cancer in parts of the world such as
India and Africa. Among the risk factors are family
history, diabetes, obesity, drug poisoning, cases of
schistosomiasis (endemic areas) history of jaundice to
hepatitis, poisoning by contaminated grains and cereals
and other factors that promote changes in hepatocytes at
DNA or not. The research aimed to examine the
histopathological effects of aflatoxin in Wistar rats (Rattus
norvegicus) in view of the carcinogenic potential of the
toxin in question. Because it is a chronic disease the
histological findings included varying degrees of necrosis,
regeneration, inflammation, steatosis, fibrosis, sclerosis
hepatoportal, granulomas and neoplasms. We believe,
therefore, that the hepatotoxic effects caused by
inoculation of aflatoxin are related to the amount of toxin
administered.

Index Terms ⎯ aflatoxine, liver cancer, intoxication,
fungi.